Wednesday, October 10, 2018 by Ellaine Castillo
Obesity has been linked to numerous health problems like cardiovascular diseases and cancer. A recent study observed that there is a link between obesity and metastasis.
Previous studies have shown that obese individuals are more at risk of cancer. Obesity is a condition where there is an accumulation of body fat and a person’s body weight exceeds the ideal weight by at least 20 percent. This causes an expansion of adipose tissue that leads to the release of adipocyte cytokines known as adipokines. These adipokines serve as signals that help the adipose tissue perform its role in regulating cell function, as well as the prevention and spread of disease. Some examples of adipokines are: leptin, TGF-beta, adiponectin, and tumor necrosis factor.
Two major causes of breast cancer deaths in women are tumor recurrence and metastasis, which occur even after the original tumor has been surgically removed. This is why removing the tumor does not necessarily cure cancer.
In this study, conducted by researchers from Helmholtz Zentrum München, Technische Universität München (TUM), and Heidelberg University Hospital, it was determined that the rate of metastasis is altered by a change in energy metabolism. This alteration is brought about by an increase in cytokine levels, specifically TGF-beta and leptin, brought about by obesity. As a result, the function of the lipogenic enzyme Acetyl-CoA-carboxylase 1 (ACC1) in fatty acid synthesis is impaired. When ACC1 is inhibited, the fatty acid precursor acetyl-CoA accumulates and turns on specific gene switches that activate gene programs involved in metastasis. In addition to this, the release of these adipokines has also been linked to chronic inflammation where tumor cell motility, invasion, and epithelial-mesenchymal transition is favored.
This study provides further insight into the link between obesity and metastasis. Now that the molecular mechanism behind has been determined, the next step is to find out therapeutic interventions for these mechanisms.
In one experimental model, the researchers used antibodies to block the leptin receptors involved in the pathway. This led to a reduced metastasis of breast cancer cells.
According to the researchers, “Blocking the signaling pathways and switching off the metastasis-related genes could be a therapeutic target.”
Overall, this study emphasizes what people have known for a long time: Obesity is dangerous to a person’s health. (Related: Obesity linked to increased health risks and birth defects.)
In order to avoid the repercussions of obesity on cancer, it is best to maintain a healthy weight. Here are some suggestions on how to naturally lose weight:
Learn more about the link between obesity and cancer metastasis by visiting Cancer.news today.